31Hypercholesterolemia changes HDL-miRNA signature and enhances HDL-miR126-3p and -5p delivery to endothelial cells modulating genes involved in vascular health
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چکیده
منابع مشابه
miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leucocyte adhesion and transmigration.
AIMS miR126-5p is processed from the miR126-3p/-5p duplex, which is expressed in endothelial cells and gives rise to the guide strand miR126-3p and the passenger strand miR126-5p. miR126-3p has prominent roles in vascular development and diseases, whereas the expression and physiological functions of miR126-5p are unknown. The purpose of this study was to evaluate the expression and role of miR...
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The superfamily of pentraxins consists of evolutionary conserved acute phase proteins characterized by the presence of a multimeric structural motif, the pentraxin domain (reviewed in1). C-reactive protein and serum amyloid P represent the short pentraxin arm of this family and are mainly produced by the liver. The long pentraxins were identified more recently as cytokine-inducible molecules ex...
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Background and purpose: Lentiviral vectors (LVs) are suitable candidates for gene delivery to cells with stable and high-level of transgene expression in target cells. MicroRNAs (miRNAs, miRs) are non-protein coding, short (~22 nucleotides) and single-stranded RNAs that act as post-transcriptional regulators of gene expression, and are involved in various cellular processes, including prolifera...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2018
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvy060.014